Archive for the ‘Energy Production’ Category

CoQ10 benefit heart failure patients

Tuesday, June 4th, 2013

Presenting the study at Heart Failure Congress 2013 of the European Society of Cardiology Heart Failure Association, lead investigator Dr Svend Aage Mortensen(Copenhagen University Hospital, Denmark) reported that major adverse cardiovascular events (MACE), a composite of unplanned hospitalization due to worsening heart failure, cardiovascular death, and the need for urgent cardiac transplantation and mechanical support, occurred in 14% of patients treated with CoQ10 compared with 25% of patients who received a placebo, a statistically significant difference (p=0.003). All-cause mortality was also significantly lower in the CoQ10-treated patients, with 9% dying compared with 17% in the placebo arm (p=0.01).

In addition to these outcomes, the Q-SYMBIO investigators reported that cardiovascular mortality and admissions for heart failure were significantly lower in those who received CoQ10. In their conclusions, the researchers stated that “CoQ10 should be considered as a part of the maintenance therapy of patients with chronic heart failure.”

Some, however, considered the recommendations to alter clinical practice on the basis of this 420-patient clinical trial premature. Dr Sanjay Kaul (Cedars-Sinai Medical Center, Los Angeles), for example, said he wants to reserve judgment on the data until they have stood up against the scrutiny of the peer-review process.

CoQ10 is an antioxidant involved in cellular-energy production. It is postulated that heart-failure patients, who have a measurable deficiency in CoQ10, would benefit from receiving the supplement.

The Q-SYMBIO study included 202 patients randomized to CoQ10 and 218 patients randomized to placebo. All patients included in the study had moderate to severe heart failure (NYHA class 3 or 4) and were receiving “current” pharmacologic therapy. Patients had an average ejection fraction of 31%, and the average age was 62 years. Within three months of treatment, investigators observed a trend toward lower levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The clinical improvements in MACE were observed after two years of receiving 100 mg of CoQ10 three times daily compared with those who received the placebo. In addition, 44% of those who received CoQ10 had an improvement in NYHA class compared with 45% of those who received placebo (p=0.047).

It is not clear as to the formulation used in the trial. The dose is 100 mg three times per day. We did discuss the difference between ubiquinone and ubiquinol in previous article. It would be good to also ascertain with measurable markers whether there was CoQ10 deficiency in the treated and placebo groups. It is not surprising to see benefits in such patients because coenzyme Q10 may be depleted in patients with heart failure and cardiomyopathy and those who are on statin treatment for high cholesterol.

The ratio of reduced to total Q10 concentration is also a useful biomarker of oxidative stress. Patients who have coenzyme Q10 deficiency also have increased risk of mitochondrial and cellular injury from excess production of free radicals.. Measurement of coenzyme Q10 concentrations in plasma can assist clinicians in detecting coenzyme Q10 deficiency states, and serve as a guide for dosing when oral supplementation is indicated.

We were not told of the formulation of the CoQ10 used in this study. Because significant inter-product variability in the absorption and bioavailability of coenzyme Q10 has been reported with over-the-counter (OTC) Q10 preparations, the Coenzyme Q10 test will also assist in verifying the extent of absorption of Q10 from those products.

CoQ10- your indispensable coworker!

Wednesday, December 30th, 2009

Coenzyme Q10

CoenzymeQ10 also known as CoQ10 or ubiquinon (from the word ubiquitous i.e widespread distribution), as a coenzyme, this nutrient aids mitochondria in the complex process of transforming food (Fats, Carbohydrates, Proteins) into ATP, the energy on which the body runs.
Virtually every cell in the human body contains coenzyme Q10. The mitochondria, the area of cells where energy is produced, contain the most coenzyme Q10. The heart and the liver, because they contain the most mitochondria per cell, contain the greatest amount of coenzyme Q10.

Coenzyme Q10 for a healthy heart

Ubiquinone, or coenzyme Q10, is an important nutrient. 2 of its primary uses are for those who are taking high cholesterol pills (the statin drugs in particular). Certain lipid-lowering drugs, such as the ‘statins’ – lovastatin, simvastatin, pravastatin – and gemfibrozil as well as oral agents which lower blood sugar, such as tolazamide and glyburide, cause a decrease in serum levels of coenzyme Q10 and reduce the effects of coenzyme Q10 supplementation .

These drugs inhibit the production of coenzyme Q10 by the liver and may cause serious complications unless one supplements coenzyme Q10 back into the diet. A prescription for lipid-lowering statin drugs should be accompanied with a recommendation to take coenzyme Q10, because if a person is deficient in coenzyme Q10, heart failure is a probability.

Beta-blockers (drugs which slow the heart rate and lower blood pressure) can inhibit coenzyme Q10-dependent enzyme reactions.

The 2nd major use of Coenzyme Q10 would be in the case of congestive heart failure, where it is particularly effective. Its importance to the human heart is illustrated by the fact that the heart may cease to function as coenzyme Q10 levels fall by 75%.
In congestive heart failure, the heart cannot pump efficiently, which slows the flow of blood to the lungs and the rest of the body. The heart can temporarily maintain the blood in several ways. It can enlarge to pump extra blood; it can beat faster; or the ventricular walls can become thicker, which can strengthen the pumping ability.

How CoQ10 Works.
ATP (adenosine triphosphate) cannot be produced without Coenzyme Q10. ATP, occurring in EVERY cell of your body, serves as a source of energy for many of your body’s biochemical processes and represents the reserve energy in your muscles.

Your heart for example, being a muscle which is continually in motion, needs a constant supply of ATP. This is where the importance of Coenzyme Q10 comes into play: ATP cannot be produced without Coenzyme Q10. Coenzyme Q10 is the catalyst for the creation of ATP.
This means that Coenzyme Q10 plays a vital role in the inner workings of your body and, for obvious reasons, is found in the highest concentration in the heart.

Food Sources of CoQ10

Our bodies can bio-synthesise some of the CoQ10 that we need. The rest is from the foods we eat. It is primarily found in fish and meat.

The highest dietary source come from fresh sardines and mackerel, the heart, liver and meat of beef, lamb and pork, eggs and plenty of vegetable sources the richest being spinach, broccoli, peanuts, wheat germ and whole grains. These should be fresh and unprocessed (no milling, canning, preserving, freezing) and grown/produced in an unpolluted environment to be considered viable.

When Supplementing with CoQ10

Softgels are the preferred delivery method over powders and capsules. Normal adult supplementation is usually 30-90 mg per daily.
For older people i.e 50yrs and above, DFH’s Ubiquinol is recommended.

CoQ10 should be taken with a meal that contains oil to improve absorption. It is fat soluble and like most fat soluble compounds is poorly absorbed from the GI tract when taken on an empty stomach.

The Miracle Nutrient, Coenzyme Q10 by Emile G Bliznakov, MD is recommended reading as regards milligram content of CoQ10 in foods plus extensive research documentation.